Relatlimab  (Synonyms: 瑞拉利单抗; BMS-986016)

Relatlimab (BMS-986016) is a human monoclonal antibody anti-LAG-3 antibody generated by immunization of transgenic mice bearing human immunoglobulin miniloci with recombinant LAG-3 protein. Relatlimab blocks LAG-3/MHC II interaction with an IC₅₀ value of 0.67 nM and LAG-3/FGL1 interaction with an IC₅₀ value of 0.019 nM. Relatlimab can be used in research of cancer^[1].

Human IgG4 kappa

Human IgG4 (S228P) kappa, Isotype Control

Human

Relatlimab (BMS-986016；0.001-100 nM) 识别天然 LAG-3 并结合原代活化的人和猕猴 CD4+ T 细胞，EC₅₀ 值分别为 0.11 nM 和 29.11 nM^[1]。
Relatlimab (0.001-10000 nM；T 细胞 (3A9-hLAG-3)) 增强t细胞杂交瘤 3A9-hLAG-3 的肽反应性，逆转 lag -3 介导的t细胞杂交瘤 3A9-hLAG-3 的抑制作用，IC₅₀值为 1.05 nM^[1]。
Relatlimab (0.001-10000 nM；原代 T 细胞) 增强超抗原刺激的人 PBMC 培养物的活化并增强 IL-2 分泌^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Relatlimab (BMS-986016；0.001-100 nM) 识别天然 LAG-3 并结合原代活化的人和猕猴 CD4+ T 细胞，EC₅₀ 值分别为 0.11 nM 和 29.11 nM^[1]。
Relatlimab (0.001-10000 nM；T 细胞 (3A9-hLAG-3)) 增强t细胞杂交瘤 3A9-hLAG-3 的肽反应性，逆转 lag -3 介导的t细胞杂交瘤 3A9-hLAG-3 的抑制作用，IC₅₀值为 1.05 nM^[1]。
Relatlimab (0.001-10000 nM；原代 T 细胞) 增强超抗原刺激的人 PBMC 培养物的活化并增强 IL-2 分泌^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1673516-98-7

液体

Colorless to light yellow

瑞拉利单抗

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

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  Human IgG4 kappa

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  Loaded Relatlimab on AHC2 biosensor, can bind LAG-3 Protein, Human (HEK293, His, HY-P70722) with an affinity constant of 8.814E-10 M as determined in BLI assay.

• [1]. Thudium K, et, al. Preclinical Characterization of Relatlimab, a Human LAG-3-Blocking Antibody, Alone or in Combination with Nivolumab. Cancer Immunol Res. 2022 Aug 18:CIR-22-0057.  [Content Brief]